My long-term interests are in the area of clinical trials and clinical trial design, particularly as they pertain to biologic and biotechnologically produced proteins. My research in this area has covered such areas as the development of statistical test procedures for bioequivalency studies, particularly those that involve matched paired designs. I have also worked extensively on the development of robust estimation and semi-parametric models for the analysis of pharmacokinetic data. Recently, I have taken an interest in pharmacoeconomic modeling and have been working on Markov models for the assessment of cost-effectiveness of new diagnostic procedures for cervical cancer. The studies I have been involved in have given me the opportunity to work extensively with researchers in the fields of immunology, hematology, and oncology. Indeed, recently I was able to publish an applied immunology textbook with a colleague of mine at Stanford. Thus, my activities have allowed me to extend my scope far beyond biostatistical research.